非黄酮类多酚在糖尿病中的潜在应用：抗炎作用

Title:Potential Application of Non-flavonoid Phenolics in Diabetes: Antiinflammatory Effects

Volume: 22 Issue: 1

Author(s): J. Miranda, A. Lasa, L. Aguirre, A. Fernandez-Quintela, I. Milton and M.P. Portillo

Affiliation:

关键词: 动物模型，培养的细胞，糖尿病，人类干预研究，抗炎，非黄酮类，多酚。

摘要: Polyphenols are members of a very large family of plant-derived compounds that may have beneficial effects on human health, and thus their study has become an increasingly important area of human nutrition research. Considering that it is increasingly accepted that chronic sub-acute inflammation plays an important role in the development of insulin resistance and of diabetes in animals and in humans, the aim of the present review is to compile information concerning the anti-inflammatory effects of non-flavonoid polyphenols on diabetes prevention and/or treatment. Most of these studies have been carried out with different cultured cells and using animal models displaying different types of diabetes, such as diabetes induced by streptozotocin or streptozotocin-nicotinamide, genetic diabetes or diabetes induced by high-fat feeding. In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1β, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes. This effect is accompanied in the vast majority of these studies by improved insulin action. In addition, some of the non-flavonoid polyphenols are also able to ameliorate or prevent several pathological alterations associated with the development of diabetes, such as nephropathy, cardiopathy or retinopathy. Very little information has been reported with regard to human studies to date. Thus, new studies are needed to confirm if the beneficial effects observed in preclinical studies can apply to human beings.

Cite this article as:

J. Miranda, A. Lasa, L. Aguirre, A. Fernandez-Quintela, I. Milton and Portillo M.P., Potential Application of Non-flavonoid Phenolics in Diabetes: Antiinflammatory Effects, Current Medicinal Chemistry 2015; 22 (1) . https://dx.doi.org/10.2174/0929867321666140815123507