Abstract
In the present work, silica supported imidazolium based sulphonic acid was developed via a simple route as a hybrid organic-inorganic solid acid catalyst. The covalent anchoring to the silica support gave a stable catalyst in quantitative yield, while the ionic tag assisted in increasing the solubility of the reactants to facilitate the reaction under solventless conditions, being a homogeneous -heterogeneous catalytic system and having the distinct advantages of both. The catalytic efficacy of the solid acid catalyst was tested for the N-Boc protection of amines. The reactivity order followed by amines was aliphatic >aromatic> hetrocyclic>aminoalcohols. This efficient protocol has advantages of better workability of catalyst, reduced reaction time, improved yield, high TON and the catalyst is both recyclable and recoverable upto seven cycles.
Keywords: Amines, N-Boc protection, organic-inorganic hybrid catalyst, sulphonic acid catalyst.
Graphical Abstract
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