Abstract
In this account, selected applications of monosaccharides, starting from sugar-based crown-ethers, in recognition of chiral ammonium cations derived from chiral amines and amino acids, are presented. The influence of sugar incorporation into the crown ether ring on binding and structural properties is discussed as well as selected methods used in determination of chiral recognition ability of these hosts. Afterwards, the differences in the design of hosts for chiral anions and receptors for cations are compared. The key-factors in construction of the sugar-based anion receptors: the structure of anion binding pocket and the role of sugar moiety, are shown. Application of these hosts in recognition of biologically important N-protected amino acids and α-hydroxy-acids, using titrations methodology under 1H NMR, UV/VIS and fluorescence control is reviewed.
Keywords: Cation and anion receptors, chiral recognition, crown ethers, monosaccharides.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
13