Abstract
6-Deoxyheptoses are rare higher-carbon sugars isolated from lipopolysaccharides (LPS) and capsular polysaccharides (CPS) of some Gram-negative bacteria (Campylobacter, Yersinia, Burkholderia, Eubacterium, Plesiomonas, and Escherichia species). They occur in numerous structural variations of the bacterial polysaccharides (PS), which are briefly summarized. Biochemical pathways involving deoxygenation of heptoses as well as possible approaches towards the chemical synthesis of these unusual monosaccharides will be discussed. The most important methods for the preparation of 6-deoxyheptoses include elongation of pentose or hexose chains by nucleophilic substitution, Wittig-type reaction, and nucleophilic addition into carbonyl group.
Keywords: 6-deoxyheptose, biosynthesis, synthesis, Burkholderia, Campylobacter, Yersinia.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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