Abstract
Nanopore based DNA Sequencing by Recognition technique relies on the sense of current between a pair of electrodes, which span nanopore and trap DNA nucleotides. The electrodes typically are tips of scanning tunneling microscope (STM) functionalized with recognition molecules that can distinguish individual DNA bases through hydrogen bonds. This manuscript aims to provide a summary of current research progress of nanopore DNA sequencing, DNA Sequencing by Recognition, evolution of recognition molecules applied in Sequencing by Recognition, and discusses the opportunities and challenges in this rapidly growing field.
Keywords: DNA sequencing, hydrogen bonds, molecular recognition, nanopore, tunneling.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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