The Effects of Obesity on the Cerebral Vasculature

Title:The Effects of Obesity on the Cerebral Vasculature

Volume: 12 Issue: 3

Author(s): Anne M. Dorrance, Nusrat Matin and Paulo W. Pires

Affiliation:

Keywords: Obesity, insulin resistance, cerebral ischemia, dementia.

Abstract: The incidence of obesity in the population is increasing at an alarming rate, with this comes an increased risk of insulin resistance (IR). Obesity and IR increase an individual’s risk of having a stroke and they have been linked to several forms of dementia. Stroke and dementia are associated with, or exacerbated by, reduced cerebral blood flow, which has recently been described in obese patients. In this review we will discuss the effects of obesity on cerebral artery function and structure. Regarding their function, we will focus on the endothelium and nitric oxide (NO) dependent dilation. NO dependent dilation is impaired in cerebral arteries from obese rats, and the majority of evidence suggests this is a result of increased oxidative stress. We will also describe the limited studies showing that inward cerebral artery remodeling occurs in models of obesity, and that the remodeling is associated with an increase in the damage caused by cerebral ischemia. We will also discuss some of the more paradoxical findings associated with stroke and obesity, including the evidence that obesity is a positive factor for stroke survival. Finally we will discuss the evidence that links these changes in vascular structure and function to cognitive decline and dementia.

Cite this article as:

Dorrance M. Anne, Matin Nusrat and Pires W. Paulo, The Effects of Obesity on the Cerebral Vasculature, Current Vascular Pharmacology 2014; 12 (3) . https://dx.doi.org/10.2174/1570161112666140423222411