The New Permeability Pathways: Targets and Selective Routes for the Development of New Antimalarial Agents

Title: The New Permeability Pathways: Targets and Selective Routes for the Development of New Antimalarial Agents

Volume: 8 Issue: 1

Author(s): Henry M. Staines, J. Clive Ellory and Kelly Chibale

Affiliation:

Keywords: malaria, channel, anion, antimalarial

Abstract: The malaria parasite, Plasmodium falciparum, spends part of its complex life cycle within the red blood cells of a human host. During this time, the parasite alters the permeability of the red blood cells plasma membrane to allow the uptake of nutrients, the removal of “waste” and volume and ion regulation of the infected cell. The increased permeability is due to the induction of new permeability pathways (NPP), which are obvious chemotherapeutic antimalarial targets and / or selective routes for drugs, which target the internal parasite. This review covers our present understanding of the NPP, the methods used to screen for putative inhibitors of the NPP, the current repertoire of NPP inhibitors and the problems that need to be addressed to realise the potential of the NPP as antimalarial targets. In addition, the review will cover the use of the NPP as specific drug delivery routes.

Cite this article as:

Staines M. Henry, Ellory Clive J. and Chibale Kelly, The New Permeability Pathways: Targets and Selective Routes for the Development of New Antimalarial Agents, Combinatorial Chemistry & High Throughput Screening 2005; 8 (1) . https://dx.doi.org/10.2174/1386207053328138

DOI https://dx.doi.org/10.2174/1386207053328138	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402