Current View on the Mechanism of Action of Perifosine in Cancer

Title:Current View on the Mechanism of Action of Perifosine in Cancer

Volume: 14 Issue: 4

Author(s): Joachim Fensterle, Babette Aicher, Irene Seipelt, Michael Teifel and Juergen Engel

Affiliation:

Keywords: APL miltefosine, cancer, perifosine.

Abstract: Perifosine treatment exhibits a complex molecular response including the inhibition of Akt or the induction of apoptosis via clustering of death receptors in lipid rafts. However, the molecular response can vary between different tumor entities and the contribution of each target pathway to the activity of Perifosine might be distinct depending on the tumor entity or the agent combined with Perifosine.

In this review we discuss the current view on the mechanism of action of perifosine in cancer and the contribution of the molecular targets of Perifosine to its activity.

Cite this article as:

Fensterle Joachim, Aicher Babette, Seipelt Irene, Teifel Michael and Engel Juergen, Current View on the Mechanism of Action of Perifosine in Cancer, Anti-Cancer Agents in Medicinal Chemistry 2014; 14 (4) . https://dx.doi.org/10.2174/1871520614666140309225912