A Facile and Quick Synthesis of 9-aryl-substituted-acridines Mediated by DMP

George      Bratulescu

doi:10.2174/157017941006140206104352

Abstract

An unexpected three components reaction was developed for acridine synthesis in solvent free medium. The reaction is carried out with commercial reagents using of microwaves in a heterogeneous medium in presence of zinc chloride and 2,2-dimethoxypropane (DMP) as water scavenger. Principal advantages of the method are: short time, high yields and easy work-up.

Keywords: Aromatic acids, acridine, bernthsen reaction, diphenylamine, DMP, water scavenger.

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Current Organic Synthesis

Title:A Facile and Quick Synthesis of 9-aryl-substituted-acridines Mediated by DMP

Volume: 10 Issue: 6

Author(s): George Bratulescu

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Keywords: Aromatic acids, acridine, bernthsen reaction, diphenylamine, DMP, water scavenger.

Abstract: An unexpected three components reaction was developed for acridine synthesis in solvent free medium. The reaction is carried out with commercial reagents using of microwaves in a heterogeneous medium in presence of zinc chloride and 2,2-dimethoxypropane (DMP) as water scavenger. Principal advantages of the method are: short time, high yields and easy work-up.

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Bratulescu George, A Facile and Quick Synthesis of 9-aryl-substituted-acridines Mediated by DMP, Current Organic Synthesis 2013; 10 (6) . https://dx.doi.org/10.2174/157017941006140206104352

DOI https://dx.doi.org/10.2174/157017941006140206104352	Print ISSN 1570-1794
Publisher Name Bentham Science Publisher	Online ISSN 1875-6271