The Role of HTS in Drug Discovery at the University of Michigan

Title:The Role of HTS in Drug Discovery at the University of Michigan

Volume: 17 Issue: 3

Author(s): Martha J. Larsen, Scott D. Larsen, Andrew Fribley, Jolanta Grembecka, Kristoff Homan, Anna Mapp, Andrew Haak, Zaneta Nikolovska-Coleska, Jeanne A. Stuckey, Duxin Sun and David H. Sherman

Affiliation:

Keywords: Drug discovery, high throughput screening, medicinal chemistry, pharmacokinetics, protein crystallography, structural biology.

Abstract: High throughput screening (HTS) is an integral part of a highly collaborative approach to drug discovery at the University of Michigan. The HTS lab is one of four core centers that provide services to identify, produce, screen and follow-up on biomedical targets for faculty. Key features of this system are: protein cloning and purification, protein crystallography, small molecule and siRNA HTS, medicinal chemistry and pharmacokinetics. Therapeutic areas that have been targeted include anti-bacterial, metabolic, neurodegenerative, cardiovascular, anti-cancer and anti-viral. The centers work in a coordinated, interactive environment to affordably provide academic investigators with the technology, informatics and expertise necessary for successful drug discovery. This review provides an overview of these centers at the University of Michigan, along with case examples of successful collaborations with faculty.

Cite this article as:

Larsen J. Martha, Larsen D. Scott, Fribley Andrew, Grembecka Jolanta, Homan Kristoff, Mapp Anna, Haak Andrew, Nikolovska-Coleska Zaneta, Stuckey A. Jeanne, Sun Duxin and Sherman H. David, The Role of HTS in Drug Discovery at the University of Michigan, Combinatorial Chemistry & High Throughput Screening 2014; 17 (3) . https://dx.doi.org/10.2174/1386207317666140109121546