Clinical Relevance of the Interaction When Switching Non-Nucleoside Reverse Transcriptase Inhibitors in Patients Infected with HIV

Title:Clinical Relevance of the Interaction When Switching Non-Nucleoside Reverse Transcriptase Inhibitors in Patients Infected with HIV

Volume: 9 Issue: 4

Author(s): Eric Dailly, Clotilde Allavena, Guillaume Deslandes, Regis Bouquie, Pascale Jolliet and Francois Raffi

Affiliation:

Keywords: Efavirenz, etravirine, nevirapine, rilpivirine, switch.

Abstract: Substitution of a non-nucleoside reverse transcriptase inhibitor (NNRTI) with another drug of the same class combined with nucleoside reverse transcriptase inhibitors is a therapeutic strategy that can improve the tolerability of antiretroviral treatment. According to the pharmacokinetic properties of NNRTIs, this substitution generates pharmacokinetic drug interactions between NNRTIs, which could decrease NNRTI exposure and virological efficacy during the introductory phase of the new NNRTI. Pharmacokinetics and clinical data are reviewed to estimate the risk for switching from efavirenz to nevirapine, efavirenz to etravirine, efavirenz to rilpivirine and nevirapine to rilpivirine.

Cite this article as:

Dailly Eric, Allavena Clotilde, Deslandes Guillaume, Bouquie Regis, Jolliet Pascale and Raffi Francois, Clinical Relevance of the Interaction When Switching Non-Nucleoside Reverse Transcriptase Inhibitors in Patients Infected with HIV, Current Clinical Pharmacology 2014; 9 (4) . https://dx.doi.org/10.2174/1574884708666131111210258