Roles of Epithelial-Mesenchymal Transition in Cancer Drug Resistance

Title:Roles of Epithelial-Mesenchymal Transition in Cancer Drug Resistance

Volume: 13 Issue: 9

Author(s): Yulong Shang, Xiqiang Cai and Daiming Fan

Affiliation:

Keywords: BCL-2, Cancer stem cell, drug resistance, EMT, microRNA, NF-B, P-glycoprotein.

Abstract: Overcoming intrinsic and acquired drug resistance is a major challenge in treating cancer. Poor responses to drug treatment can result in metastasis, cancer dissemination and death. Recently, the epithelial-mesenchymal transition (EMT) has been found to play a critical role in cancer drug resistance, but the nature of this intrinsic link remains unclear. This review summarizes recent advances in the understanding of drug resistance and focuses especially on the association between EMT and drug resistance. We discuss the roles of EMT in regulating drug resistance across different types of cancer, focusing simultaneously on the molecular mechanisms and potential pathways involved in the regulation of drug resistance by EMT. In addition, we discuss potential therapeutic strategies to target EMT to reverse drug resistance.

Cite this article as:

Shang Yulong, Cai Xiqiang and Fan Daiming, Roles of Epithelial-Mesenchymal Transition in Cancer Drug Resistance, Current Cancer Drug Targets 2013; 13 (9) . https://dx.doi.org/10.2174/15680096113136660097