Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents

Title:Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents

Volume: 14 Issue: 6

Author(s): Vikas Kumar, Akshay Kumar, Vommina V. Sureshbabu and Swapandeep S. Chimni

Affiliation:

Keywords: Amino acid residues, anticancer therapy, thiourea derivatives.

Abstract: Synthesis of new chiral thiourea derivatives (27 examples) as anticancer agents has been described. Three compound 7d (NSC code 761448/1), 7e1 (NSC code 767161/1), and 7e3 (NSC code 767160/1) were found to exhibit higher anticancer activity than 5-fluorouracil against Colon cancer, Melanoma, Ovarian cancer, and Breast cancer subpanels. The effect of stereochemistry of amino acid residues on the tumor growth inhibitory activity has also been studied.

Cite this article as:

Kumar Vikas, Kumar Akshay, Sureshbabu V. Vommina and Chimni S. Swapandeep, Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents, Anti-Cancer Agents in Medicinal Chemistry 2014; 14 (6) . https://dx.doi.org/10.2174/18715206113136660368