Focus on Microwaves Assisted Halogen-halogen Exchange Reaction Conditions on 2-Halopyridines

Title:Focus on Microwaves Assisted Halogen-halogen Exchange Reaction Conditions on 2-Halopyridines

Volume: 1 Issue: 1

Author(s): Serge Perato, Marcella De Giorgi, Gregory Burzicki, Florent Legalite, Sylvain Rault and Anne Sophie Voisin-Chiret

Affiliation:

Keywords: Acetyl chloride, 2, 3-dihalopyridine, 2, 4-dihalopyridine, 2, 6-diahlopyridine, 2-halopyridine, halogen exchange, regioselectivity, microwaves, sodium iodide, suzuki-Miyaura cross-coupling reaction.

Abstract: This paper describes an optimised microwave irradiation methodology on various substituted pyridines in order to realise a halogen-halogen exchange. This protocol provides an efficient and simple methodology to improve the reactivity of some positions on the pyridine ring towards metallocatalysed reactions. Influence of various substituents has been explored and limiting factors of reaction have been highlighted.

Cite this article as:

Perato Serge, Giorgi De Marcella, Burzicki Gregory, Legalite Florent, Rault Sylvain and Voisin-Chiret Sophie Anne, Focus on Microwaves Assisted Halogen-halogen Exchange Reaction Conditions on 2-Halopyridines, Current Microwave Chemistry 2014; 1 (1) . https://dx.doi.org/10.2174/22133356114019990003