Synthesis of 1,4-dihydropyridine Derivatives via One Pot Multicomponent Condensation in Water

Arash      Ghorbani-Choghamarani; Masoomeh      Norouzi

doi:10.2174/15701786113109990012

Abstract

A facile and efficient one-pot preparation of a new series of 1,4-dihydropyridines has been reported via a threecomponent reaction of nano aluminum nitride, aromatic aldehydes and benzyl-3-oxobutanoate or 2-methoxyethyl-3- oxobutanoateat 80 °C in water. Using this methodology, Hantzsch1,4-dihydropyridine derivatives were synthesized in a simple pathway without the use of a catalyst or an organic solvent.

Keywords: 1, 4-Dihydropyridine, Hantzsch reaction, One-pot condensation, Multicomponent, Aluminum nitride.

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Letters in Organic Chemistry

Title:Synthesis of 1,4-dihydropyridine Derivatives via One Pot Multicomponent Condensation in Water

Volume: 10 Issue: 8

Author(s): Arash Ghorbani-Choghamarani and Masoomeh Norouzi

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Keywords: 1, 4-Dihydropyridine, Hantzsch reaction, One-pot condensation, Multicomponent, Aluminum nitride.

Abstract: A facile and efficient one-pot preparation of a new series of 1,4-dihydropyridines has been reported via a threecomponent reaction of nano aluminum nitride, aromatic aldehydes and benzyl-3-oxobutanoate or 2-methoxyethyl-3- oxobutanoateat 80 °C in water. Using this methodology, Hantzsch1,4-dihydropyridine derivatives were synthesized in a simple pathway without the use of a catalyst or an organic solvent.

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Ghorbani-Choghamarani Arash and Norouzi Masoomeh, Synthesis of 1,4-dihydropyridine Derivatives via One Pot Multicomponent Condensation in Water, Letters in Organic Chemistry 2013; 10 (8) . https://dx.doi.org/10.2174/15701786113109990012