Synthesis of Allosamidin Analogue Di-N-acetyl-β-chitobiosyl N-Glycoaminooxazoline

Title:Synthesis of Allosamidin Analogue Di-N-acetyl-β-chitobiosyl N-Glycoaminooxazoline

Volume: 10 Issue: 8

Author(s): Gangliang Huang, Shuangquan Shu and Fei Cheng

Affiliation:

Keywords: Di-N-acetyl-β-chitobiosyl N-glycoaminooxazoline, Solid-phase synthesis, Glycosylation, Analogue.

Abstract: The solid-phase synthesis of di-N-acetyl-β-chitobiosyl N-glycoaminooxazoline 2 was studied. The synthesis was gone along using the N-benzyloxycarbonyl (Cbz) protected trichloroacetimidates 11 and 13 as donors, polystyrene as support, and o-nitrobenzyl ether tether as linker. The compound 2 was high-efficiently offered by three glycosylations, catalytic hydrogenolysis, acetylation, deacetylation, and photolysis, respectively.

Cite this article as:

Huang Gangliang, Shu Shuangquan and Cheng Fei, Synthesis of Allosamidin Analogue Di-N-acetyl-β-chitobiosyl N-Glycoaminooxazoline, Letters in Drug Design & Discovery 2013; 10 (8) . https://dx.doi.org/10.2174/15701808113109990008

DOI https://dx.doi.org/10.2174/15701808113109990008	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X