Synthesis of N-protected Non-proteinogenic α-amino Acid Esters by Using Trichloroacetimidate and Acetate Coupling Methods

Title:Synthesis of N-protected Non-proteinogenic α-amino Acid Esters by Using Trichloroacetimidate and Acetate Coupling Methods

Volume: 17 Issue: 17

Author(s): Ibrahim. A. I. Ali and Walid Fathalla

Affiliation:

Keywords: Non-proteinogenic amino acids, Trichloroacetimidate coupling method, Acetate coupling method, C-C bond formation, Cnucleophiles.

Abstract: A series of N-protected non-proteinogenic α-amino acid esters have been prepared. The key step in this synthesis is the treatment of trichloroacetimidate 3, 8 or acetate 4, 9 derivatives with Lewis acid and C-active nucleophiles to afford the desired products via C-C bond formation and the introduction of substituents at the α-position of the amino acid in good yields and short reaction time.

Cite this article as:

Ali A. I. Ibrahim. and Fathalla Walid, Synthesis of N-protected Non-proteinogenic α-amino Acid Esters by Using Trichloroacetimidate and Acetate Coupling Methods, Current Organic Chemistry 2013; 17 (17) . https://dx.doi.org/10.2174/13852728113179990036