Abstract
Synthesis of triazole based unnatural amino acids, triazole bis-amino acids and β-amino triazole has been described via stereo and regio-selective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW irradiation conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of triazole modified unnatural amino acids.
Keywords: Sulfamidates, Click chemistry, Unnatural amino acids, Triazole, Microwave.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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