Synthesis of a Novel Class of gem-Phosphonate-Phosphates by Reductive Cleavage of the Isoxazolidine Ring

Title:Synthesis of a Novel Class of gem-Phosphonate-Phosphates by Reductive Cleavage of the Isoxazolidine Ring

Volume: 11 Issue: 3

Author(s): Olga Bortolini, Iqbal Mulani, Antonio De Nino, Loredana Maiuolo, Alessandro Melicchio, Beatrice Russo and Donatella Granchi

Affiliation:

Keywords: Apolipoprotein E, bisphosphonates, gem-phosphonate-phosphate rearrangement, isoxazolidines, ring opening, transition-metal carbonyls.

Abstract: A new series of gem-phosphonate-phosphates bearing N-alkyl groups and aromatic substituents has been prepared by reductive cleavage of the isoxazolidine ring with metal carbonyls, using the gem-phosphonate-phosphate rearrangement.

Cite this article as:

Bortolini Olga, Mulani Iqbal, Nino De Antonio, Maiuolo Loredana, Melicchio Alessandro, Russo Beatrice and Granchi Donatella, Synthesis of a Novel Class of gem-Phosphonate-Phosphates by Reductive Cleavage of the Isoxazolidine Ring, Current Organic Synthesis 2014; 11 (3) . https://dx.doi.org/10.2174/15701794113109990061