From Gastroprotective to Ulcerogenic Effects of Glucocorticoids: Role of Long-Term Glucocorticoid Action

Ludmila      Filaretova; Tatiana      Podvigina; Tatiana      Bagaeva; Olga      Morozova

doi:10.2174/13816128113199990419

Abstract

Glucocorticoids may have dual action on the gastric mucosa: gastroprotective and ulcerogenic. In this article, we review the data which suggested that an initial action of endogenous glucocorticoids, including stress-produced ones as well as exogenous glucocorticoids is gastroprotective and consider possible mechanisms of the conversion of physiological gastroprotective action of glucocorticoid hormones to their pathological ulcerogenic effect.

Keywords: The hypothalamic-pituitary-adrenocortical axis, glucocorticoids, dexamethasone, gastric mucosa, stress, indomethacin, injury, gastroprotection.