Comparison between Coacervation Property and Secondary Structure of Synthetic Peptides, Ile-containing Elastin-derived Pentapeptide Repeats

Title:Comparison between Coacervation Property and Secondary Structure of Synthetic Peptides, Ile-containing Elastin-derived Pentapeptide Repeats

Volume: 20 Issue: 8

Author(s): Iori Maeda, Suguru Taniguchi, Junko Ebina, Noriko Watanabe, Takao Hattori and Takeru Nose

Affiliation:

Keywords: CD, coacervation, elastin, FT-IR, secondary structure, type II β–turn.

Abstract: A series of Ile-containing elastin-derived peptide-analogs, (Ile-Pro-Gly-Val-Gly)n (n=7–10) possessing remarkable and reversible coacervation property were newly synthesized. In comparison with the known elastin-derived peptideanalogs, which were so-called polypeptides, the obtained 35 to 50 mer peptides, (IPGVG)n (n=7–10) were significantly low molecular sized-polypeptides. However, they clearly exhibited coacervation property as same as the polypeptides did. Because of their low molecular size, spectrographic analyses of (IPGVG)n (n=7–10) became feasible to carry out. As results of secondary structural analyses by CD and FT-IR, it was found that the coacervation property of the peptides is clearly attributed to the ordered secondary-structures, mainly, type II β–turn.

Cite this article as:

Maeda Iori, Taniguchi Suguru, Ebina Junko, Watanabe Noriko, Hattori Takao and Nose Takeru, Comparison between Coacervation Property and Secondary Structure of Synthetic Peptides, Ile-containing Elastin-derived Pentapeptide Repeats, Protein & Peptide Letters 2013; 20 (8) . https://dx.doi.org/10.2174/0929866511320080007

DOI https://dx.doi.org/10.2174/0929866511320080007	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305