Non-Genotoxic Assessment of a Natural Antimicrobial Agent: Squalamine

Kamel      Alhanout; Carole D.      Giorgio; Michel D.      Meo; Jean M.      Brunel

doi:10.2174/22113525113119990114

Abstract

Squalamine, a natural aminosterol compound isolated from the dogfish shark Squalus acanthias, is reported to possess high antimicrobial activities. Herein, we assessed its in vitro genotoxic properties by using the Ames test and the micronucleus assay. All the experimental results demonstrate that squalamine is a non genotoxic molecule and call for further work to evaluate its potent human therapeutic use as a new class of antinfectious agents.

Keywords: Ames test, antimicrobial agent, non-genotoxic, squalamine.

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Anti-Infective Agents

Title:Non-Genotoxic Assessment of a Natural Antimicrobial Agent: Squalamine

Volume: 12 Issue: 1

Author(s): Kamel Alhanout, Carole D. Giorgio, Michel D. Meo and Jean M. Brunel

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Keywords: Ames test, antimicrobial agent, non-genotoxic, squalamine.

Abstract: Squalamine, a natural aminosterol compound isolated from the dogfish shark Squalus acanthias, is reported to possess high antimicrobial activities. Herein, we assessed its in vitro genotoxic properties by using the Ames test and the micronucleus assay. All the experimental results demonstrate that squalamine is a non genotoxic molecule and call for further work to evaluate its potent human therapeutic use as a new class of antinfectious agents.

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Alhanout Kamel, Giorgio Carole D., Meo Michel D. and Brunel Jean M., Non-Genotoxic Assessment of a Natural Antimicrobial Agent: Squalamine, Anti-Infective Agents 2014; 12 (1) . https://dx.doi.org/10.2174/22113525113119990114