Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines

Title:Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines

Volume: 13 Issue: 10

Author(s): Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, João B. Fernandes, Maria Fátima G. F. da Silva, Paulo C. Vieira, Maria S. J. Nascimento, Gabriela M. Almeida, M. Helena Vasconcelos, Pannee Pakkong and Madalena M. M. Pinto

Affiliation:

Keywords: Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.

Abstract: Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.

Cite this article as:

Cazal M. Cristiane, Choosang Kantima, Severino Gisele P. Vanessa, Fernandes B. João, Silva Fátima G. F. da Maria, Vieira C. Paulo, Nascimento S. J. Maria, Almeida M. Gabriela, Vasconcelos Helena M., Pakkong Pannee and Pinto M. M. Madalena, Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (10) . https://dx.doi.org/10.2174/1871520613666131125122857