Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09

Title:Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09

Volume: 10 Issue: 6

Author(s): George V. Teplov, Evgeny V. Suslov, Vladimir V. Zarubaev, Anna A. Shtro, Liubov A. Karpinskaya, Artem D. Rogachev, Dina V. Korchagina, Konstantin P. Volcho, Nariman F. Salakhutdinov and Oleg I. Kiselev

Affiliation:

Keywords: Adamantyamine, Antiviral, (H1N1)pdm09, Influenza, Monoterpenoid, Resistance.

Abstract: A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.

Cite this article as:

Teplov George V., Suslov Evgeny V., Zarubaev Vladimir V., Shtro Anna A., Karpinskaya Liubov A., Rogachev Artem D., Korchagina Dina V., Volcho Konstantin P., Salakhutdinov Nariman F. and Kiselev Oleg I., Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09, Letters in Drug Design & Discovery 2013; 10 (6) . https://dx.doi.org/10.2174/1570180811310060002

DOI https://dx.doi.org/10.2174/1570180811310060002	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X