Catalytic Asymmetric Synthesis of γ-Butenolides by Direct Vinylogous Reactions

Title:Catalytic Asymmetric Synthesis of γ-Butenolides by Direct Vinylogous Reactions

Volume: 13 Issue: 6

Author(s): Lin Yan, Xiaohong Wu, Hongjun Liu, Liangying Xie and Zhiyong Jiang

Affiliation:

Keywords: Asymmetric synthesis, Vinylogous, Butenolides

Abstract: The γ-butenolide structural motif is a prominent feature in many bioactive natural products and drugs. This short review summarizes catalytic asymmetric synthesis of γ-butenolides through direct vinylogous reactions by metal complexes and organocatalysts. In light of building chiral γ-tertiary and quaternary carbon centers of butenolides, three synthetic strategies are included: 1) the reactions with furanone derivatives as nucleophiles, 2) olefination of γ,γ- disubstituted butenolides and 3) the reactions by using γ,γ-disubstituted butenolides as nucleophiles.

Cite this article as:

Yan Lin, Wu Xiaohong, Liu Hongjun, Xie Liangying and Jiang Zhiyong, Catalytic Asymmetric Synthesis of γ-Butenolides by Direct Vinylogous Reactions, Mini-Reviews in Medicinal Chemistry 2013; 13 (6) . https://dx.doi.org/10.2174/1389557511313060007