Copper-Catalyzed Synthesis of Isoquinolines by the Cyclocondensation of ortho- Alkynyl Aromatic Aldehydes or Ketones with Urea

Title:Copper-Catalyzed Synthesis of Isoquinolines by the Cyclocondensation of ortho- Alkynyl Aromatic Aldehydes or Ketones with Urea

Volume: 10 Issue: 2

Author(s): Jia Ju and Ruimao Hua

Affiliation:

Keywords: o-Alkynyl aromatic aldehyde, o-Alkynyl aromatic ketone, cyclocondensation, isoquinoline derivative, urea

Abstract: A simple and efficient synthesis of isoquinoline derivatives by the condensation of ortho-alkynyl aromatic aldehydes/ketones with urea in the presence of copper salts is developed.

Cite this article as:

Ju Jia and Hua Ruimao, Copper-Catalyzed Synthesis of Isoquinolines by the Cyclocondensation of ortho- Alkynyl Aromatic Aldehydes or Ketones with Urea, Current Organic Synthesis 2013; 10 (2) . https://dx.doi.org/10.2174/1570179411310020007