Quinolines as Chemotherapeutic Agents for Leishmaniasis

Title:Quinolines as Chemotherapeutic Agents for Leishmaniasis

Volume: 13 Issue: 5

Author(s): Kristie A. Reynolds, Wendy A. Loughlin and David J. Young

Affiliation:

Keywords: Leishmaniasis, quinolines, affordable chemotherapies

Abstract: The development of leishmanicidal quinolines and their in vitro (promastigote and amastigote) and, where applicable, in vivo activities are reviewed. This survey provides a direct comparison of bioactivity across different species (e.g. L. donovani, L. amazonensis, L. chagasi, L infantum), and in different animal models (e.g. L. donovani Balb/c mice and L. donovani infected hamsters). The progress of selected quinolines through pre-clinical development and phase I/II trials, and the lead quinoline drugs sitamaquinine and Imiquimod, are discussed in conjunction with delivery systems and combination therapies.

Cite this article as:

A. Reynolds Kristie, A. Loughlin Wendy and J. Young David, Quinolines as Chemotherapeutic Agents for Leishmaniasis, Mini-Reviews in Medicinal Chemistry 2013; 13 (5) . https://dx.doi.org/10.2174/1389557511313050010