Abstract
This review deals with synthetic potential and utility of benzoylacetonitrile in the synthesis of pyridine derivatives. The reactions are subdivided into groups that cover the synthetic methods of pyridine derivatives from benzoylacetonitrile e.g. self condensation, Friedlander reaction, Michael Addition reaction, addition to enaminones, reaction with enamino-nitriles or enamino-esters, and one-pot three component reactions. A brief account on the synthesis of benzoylacetonitrile was also displayed.
Keywords: Benzoylacetonitrile, Pyridines, Quinolines, Naphthyridines, Enaminones, Benzonitrile, Acetophenone, Haloacetophenone, bis(trifluoromethylsulfonyl)imide (PNIPAM), Electrosteric stabilisation
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
13