Abstract
Suzuki-Miyaura cross-coupling of free (NH) indazoles is described. The reactions are carried out under microwave irradiation using various 3-bromoindazoles and boronic acids. Different reaction conditions were investigated and the best results were obtained using Pd(PPh3)4 and Cs2CO3 in a mixture of 1,4-dioxane/EtOH/H2O at 140 °C under microwave irradiation.
Keywords: Suzuki-Miyaura cross-coupling, Free (NH) indazoles, Microwave irradiation, Palladium-mediated cross-coupling, Boronic acids, Sealed vessel, 3-chloroindazole, Indazoles, Cs2CO3, Pyridin-3-ylboronic acid
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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