Abstract
Since the discovery that indium could affect a Barbier-type allylation of carbonyls in water over a decade ago, interest in the utility of indium metal and its salts to influence organic transformations has increased exponentially. Control of chemo-, regio-, and especially stereoselectivity in indium-mediated reactions has proven to be a challenge, however, examples of such discerning processes are now beginning to appear on a regular basis. Indium has been found to be effective in the allylation of carbonyls, carbometallation of some alkenes and alkynes. It has also been shown to be a reducing agent for a variety of organic functional groups, mediators for a variety of coupling reactions, and more recently indium reagents have been utilized as initiators for radical transformations. This review presents an overview of the development of stereoselective indium-mediated organometallic reactions.
Keywords: Diastereoselectivity, enantioselectivity, Pseudopterane, Chiral Acceptors, allylindium species, Propargyl Reactions
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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