A Catalytic Dual-Activation Approach to the Significant 3,4- Dihydropyrimidin-2(1H)-one System via the Bignelli Reaction

Title:A Catalytic Dual-Activation Approach to the Significant 3,4- Dihydropyrimidin-2(1H)-one System via the Bignelli Reaction

Volume: 10 Issue: 1

Author(s): Boudjemaa Boumoud, Imene Mennana, Taoues Boumoud and Abdelmadjid Debache

Affiliation:

Keywords: Biginelli reaction, cooperative catalysis, dihydropyrimidin-2(1H)-one, DHPMs, DMAP, dual activation, FeCl3, Lewis acid/ Lewis base system, calcium channel, catalysts

Abstract: In many chemical processes, Lewis acids and bases are used to activate reactants simultaneously or sequentially. The integration of both Lewis base and Lewis acid has great potential to enhance known reactivity and drive the development of new chemical reactions with high value. In this topic, we disclose herein, the synthesis of 3,4- Dihydropyrimidin-2(1H)-ones, via one-pot three-component Biginelli condensation, in the presence of Lewis acid/ tertiary amine as a novel cooperative catalytic system. The high activity and the synergistic effect of this system are well pronounced.

Cite this article as:

Boumoud Boudjemaa, Mennana Imene, Boumoud Taoues and Debache Abdelmadjid, A Catalytic Dual-Activation Approach to the Significant 3,4- Dihydropyrimidin-2(1H)-one System via the Bignelli Reaction, Letters in Organic Chemistry 2013; 10 (1) . https://dx.doi.org/10.2174/1570178611310010004