Abstract
Amorphous materials have always been an essential part of pharmaceutical research They are important because of their characteristic solubility characteristics, common occurrence, and physicochemical instability relative to corresponding crystals. Some pharmaceutical agents have a tendency to exist as amorphous solids, while others require prevention of their crystallization to remain in the amorphous state in order to achieve desire characteristics. Amorphous solids can be stabilized by some common pharmaceutical processes like solid dispersion technique, solvent evaporation, milling, lipid dispersion. This article reviews the methodologies and approaches for stabilization of amorphous form.
Keywords: Amorphous solid, crystallization, dispersion techniques, milling, physicochemical instability, stabilization
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