Cytotoxicity and Antibacterial Activity of Chitosan-organic Rectorite Intercalated Nanofibrous Mats

Title:Cytotoxicity and Antibacterial Activity of Chitosan-organic Rectorite Intercalated Nanofibrous Mats

Volume: 9 Issue: 1

Author(s): Jing Du, Xueyong Li, Chen Yang, Wei Li, Weijuan Huang, Rong Huang, Xue Zhou and Hongbing Deng

Affiliation:

Keywords: Antibacterial activity, bacterial activity, cytotoxicity, chitosan, electrospinning, intercalation, organic rectorite

Abstract: The chitosan (CS)-organic rectorite (OREC) composites are prepared with the method of solution intercalation. Electrospun nanofibrous mats are made from intercalated CS-OREC composites at different mass ratios. The properties and structure of intercalated CS-OREC can be verified by small angle X-ray diffraction (SAXRD) and transmission electron microscopy (TEM) micrographs. Energy dispersive X-ray (EDX) spectroscopy and fourier transform infrared (FT-IR) spectra reveal that OREC presents in the composite nanofibrous mats. The MTT assay indicates that the cytotoxicity of the intercalated CS-OREC nanofibrous mats is low. Besides, the content of OREC in nanofibrous mats has a significant influence on the viability of cells. Antibacterial test confirms that OREC can increase the inhibition rate of the nanofibrous mats against Escherichia coli.

Cite this article as:

Du Jing, Li Xueyong, Yang Chen, Li Wei, Huang Weijuan, Huang Rong, Zhou Xue and Deng Hongbing, Cytotoxicity and Antibacterial Activity of Chitosan-organic Rectorite Intercalated Nanofibrous Mats, Current Nanoscience 2013; 9 (1) . https://dx.doi.org/10.2174/1573413711309010004