Preparation and Property Screening of the Solid Inclusion Complex of Norfloxacin with p-Sulfonated Calix[4]arene

Title: Preparation and Property Screening of the Solid Inclusion Complex of Norfloxacin with p-Sulfonated Calix[4]arene

Volume: 10 Issue: 6

Author(s): Qin Lu, Yunyou Zhou, Junyong Sun, Lian Wu, Huapeng Yu, Hongwei Xu and Lun Wang

Affiliation:

Keywords: p-Sulfonated calix[4]arene, norfloxacin, solid inclusion complex

Abstract: The complexation of norfloxacin (NFLX) by p-sulfonated calix[4]arene (SC4A) in aqueous solution has been studied by fluorescence spectroscopy and 1H NMR spectroscopy. A 1:1 stoichiometry and a 8086 L mol-1 stability constant of the NFLX-SC4A complex was obtained by spectrofluorometric titrations. The equimolar solid state inclusion complex of NFLX-SC4A was prepared by the co-precipitation method and then characterized by various techniques, including differential scanning calorimetry (DSC), X-ray powder diffractometry (XRD), Fourier-transform infrared analysis (FT-IR) and scanning electron microscopy (SEM). The experimental results of these chemical property screenings confirmed that NFLX and SC4A can form a stable host-guest complex in the solid state, and SC4A appears to function as a complexing and solubilizing agent for NFLX.

Cite this article as:

Lu Qin, Zhou Yunyou, Sun Junyong, Wu Lian, Yu Huapeng, Xu Hongwei and Wang Lun, Preparation and Property Screening of the Solid Inclusion Complex of Norfloxacin with p-Sulfonated Calix[4]arene, Combinatorial Chemistry & High Throughput Screening 2007; 10 (6) . https://dx.doi.org/10.2174/138620707781996448

DOI https://dx.doi.org/10.2174/138620707781996448	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402