Synthesis of a Common Tetrasaccharide Repeating Unit of the O-antigen of Enteroinvasive Escherichia coli O143 and Shigella boydii Type 81

Abhishek      Santra; Anup      Kumar Misra

doi:10.2174/1570179411310010010

Abstract

A concise chemical synthesis of the common tetrasaccharide corresponding to the O-antigen of enteroinvasive Escherichia coli O143 and Shigella boydii type 8 has been achieved in excellent yield. Application of [2+2] block glycosylation and late stage oxidation of primary hydroxyl groups to the carboxylic groups are notable features in the synthetic strategy.

Keywords: Escherichia coli, Shigella boydii, O-antigen, tetrasaccharide, dysentery

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Title:Synthesis of a Common Tetrasaccharide Repeating Unit of the O-antigen of Enteroinvasive Escherichia coli O143 and Shigella boydii Type 81

Volume: 10 Issue: 1

Author(s): Abhishek Santra and Anup Kumar Misra

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Keywords: Escherichia coli, Shigella boydii, O-antigen, tetrasaccharide, dysentery

Abstract: A concise chemical synthesis of the common tetrasaccharide corresponding to the O-antigen of enteroinvasive Escherichia coli O143 and Shigella boydii type 8 has been achieved in excellent yield. Application of [2+2] block glycosylation and late stage oxidation of primary hydroxyl groups to the carboxylic groups are notable features in the synthetic strategy.

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Santra Abhishek and Kumar Misra Anup, Synthesis of a Common Tetrasaccharide Repeating Unit of the O-antigen of Enteroinvasive Escherichia coli O143 and Shigella boydii Type 81, Current Organic Synthesis 2013; 10 (1) . https://dx.doi.org/10.2174/1570179411310010010