Abstract
During the last decade skin biopsy has been confirmed as a tool to provide diagnostic information on some peripheral neuropathies. Most studies were focused on intraepithelial nerve fibers and few studies have investigated large myelinated fibers or whether corpuscles in human skin change quantitatively or qualitatively in pathologies of the peripheral or central nervous system. The main objective of this article is to provide a comprehensive review of Meissner’s corpuscles including their distribution, density and age changes, development, molecular composition, cellular anatomy and physiology. We also describe their involvement in several pathologies and suggest including this dermal structure in the routine study of skin biopsies, looking for changes to be used as potential markers for several disorders. Finally the article draws the main aspects of how to study Meissner’s corpuscles in skin biopsies and gives a view on future perspectives for implementing their use in clinical practice.
Keywords: Meissner’s corpuscles, skin biopsy, neuropathy, guidelines, intraepithelial, myelinated fibers, cellular anatomy, phosphorylated neurofilaments, immunoreactivity, Schwann cells
CNS & Neurological Disorders - Drug Targets
Title:Clinical Implication of Meissner’s Corpuscles
Volume: 11 Issue: 7
Author(s): Jose A. Vega, Alfonso Lopez-Muniz, Marta G. Calavia, Olivia Garcia-Suarez, Juan Cobo, Jesus Otero, Oscar Arias-Carrion, Pablo Perez-Pinera and Manuel Menendez-Gonzalez
Affiliation:
Keywords: Meissner’s corpuscles, skin biopsy, neuropathy, guidelines, intraepithelial, myelinated fibers, cellular anatomy, phosphorylated neurofilaments, immunoreactivity, Schwann cells
Abstract: During the last decade skin biopsy has been confirmed as a tool to provide diagnostic information on some peripheral neuropathies. Most studies were focused on intraepithelial nerve fibers and few studies have investigated large myelinated fibers or whether corpuscles in human skin change quantitatively or qualitatively in pathologies of the peripheral or central nervous system. The main objective of this article is to provide a comprehensive review of Meissner’s corpuscles including their distribution, density and age changes, development, molecular composition, cellular anatomy and physiology. We also describe their involvement in several pathologies and suggest including this dermal structure in the routine study of skin biopsies, looking for changes to be used as potential markers for several disorders. Finally the article draws the main aspects of how to study Meissner’s corpuscles in skin biopsies and gives a view on future perspectives for implementing their use in clinical practice.
Export Options
About this article
Cite this article as:
A. Vega Jose, Lopez-Muniz Alfonso, G. Calavia Marta, Garcia-Suarez Olivia, Cobo Juan, Otero Jesus, Arias-Carrion Oscar, Perez-Pinera Pablo and Menendez-Gonzalez Manuel, Clinical Implication of Meissner’s Corpuscles, CNS & Neurological Disorders - Drug Targets 2012; 11 (7) . https://dx.doi.org/10.2174/1871527311201070856
DOI https://dx.doi.org/10.2174/1871527311201070856 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Subject Index to Volume 4
Current Drug Targets - Cardiovascular & Hematological Disorders Imaging the Neural Effects of Cannabinoids: Current Status and Future Opportunities for Psychopharmacology
Current Pharmaceutical Design Use of Human Umbilical Cord Blood (HUCB) Cells to Repair the Damaged Brain
Current Neurovascular Research Brain Hyperthermia During Physiological and Pathological Conditions: Causes, Mechanisms, and Functional Implications
Current Neurovascular Research Alzheimer's Disease and Natural Products: Future Regimens Emerging from Nature
Current Topics in Medicinal Chemistry Astrocyte-Microglia Cooperation in the Expression of a Pro-Inflammatory Phenotype
CNS & Neurological Disorders - Drug Targets Hormetic Potential of Sulforaphane (SFN) in Switching Cells’ Fate Towards Survival or Death
Mini-Reviews in Medicinal Chemistry Patient-Specific Induced Pluripotent Stem Cell Models in Mitochondrial Diseases
Current Stem Cell Research & Therapy Microbubbles as Drug Delivery Systems in Cerebrovascular Diseases
Recent Patents on Cardiovascular Drug Discovery Purine Ionotropic (P2X) Receptors
Current Pharmaceutical Design Programmed Axon Death, Synaptic Dysfunction and the Ubiquitin Proteasome System
Current Drug Targets - CNS & Neurological Disorders Non-Selective Cation Channel Blockers: Potential Use in Nervous System Basic Research and Therapeutics
Mini-Reviews in Medicinal Chemistry Cerebrospinal Fluid Proteomes: From Neural Development to Neurodegenerative Diseases
Current Proteomics Stem Cells as a Potential Therapeutic Option for Treating Neurodegenerative Diseases
Current Stem Cell Research & Therapy The ORL-1 Receptor System: Are There Opportunities for Antagonists in Pain Therapy?
Current Topics in Medicinal Chemistry Evidence of Nestin-Positive Cells in the Human Cutaneus Meissner and Pacinian Corpuscles
CNS & Neurological Disorders - Drug Targets miR-666-3p Mediates the Protective Effects of Mesenchymal Stem Cell-derived Exosomes Against Oxygen-glucose Deprivation and Reoxygenation- induced Cell Injury in Brain Microvascular Endothelial Cells via Mitogen-activated Protein Kinase Pathway
Current Neurovascular Research Patent Selections:
Recent Patents on Regenerative Medicine Gene Therapy Approaches to Ataxias
Current Gene Therapy Activity-Dependent Neurorehabilitation Beyond Physical Trainings: “Mental Exercise” Through Mirror Neuron Activation
CNS & Neurological Disorders - Drug Targets