Abstract
Research on steroid biooxidation is being pursued for development of processes exploitable by the pharmaceutical industry, and also for the purpose of preparation of potentially useful steroid analogues which are otherwise inaccessible. The use of enzymes provides high regio- and stereoselectivity of the reaction to be performed. In this work a review of recent and important findings related to microbial and enzymatic biotransformations of steroidal compounds including hydroxylation, Baeyer-Villiger oxidation, dehydrogenation and sterol side-chain cleavage is presented, with emphasis on processes of practical biotechnological importance. Although some of these bioconversions are well-established, efforts are ongoing in order to increase their efficiency as well as to discover novel steroidal compounds and acquire recombinant microorganisms capable of performing desired steroid biotransformations.
Keywords: Baeyer-Villiger Oxidation, Biotransformation of Steroids, Dehydrogenation, Microbial Transformation, Stereoselective Hydroxylation, Sterol Side-Chain Cleavage
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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