Comparative Genomics and Systems Biology of Malaria Parasites Plasmodium

Hong      Cai; Zhan      Zhou; Jianying      Gu; Yufeng      Wang

doi:10.2174/157489312803900965

Abstract

Malaria is a serious infectious disease that causes over one million deaths yearly. It is caused by a group of protozoan parasites in the genus Plasmodium. No effective vaccine is currently available and the elevated levels of resistance to drugs in use underscore the pressing need for novel antimalarial targets. In this review, we survey omics centered developments in Plasmodium biology, which have set the stage for a quantum leap in our understanding of the fundamental processes of the parasite life cycle and mechanisms of drug resistance and immune evasion.

Keywords: Drug, genomics, interactome, malaria, plasmodium, proteomics, systems biology, transcriptomics, vaccine