A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone

Title:A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone

Volume: 9 Issue: 10

Author(s): Alan L. Myers, Yan-Ping Zhang, Mark A. Kramer, William G. Bornmann, Ahmed Kaseb, Peiying Yang and Hai T. Tran

Affiliation:

Keywords: Dithymoquinone, photodimerization, thymoquinone, X-ray structure

Abstract: An updated and practical approach to the synthesis of dithymoquinone via one-step photoirradiation of thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone) is described. Synthesis resulted in a 55 % yield of one structural isomer (trans-anti derivative), as confirmed by HPLC, NMR spectroscopy and first ever single-crystal X-ray diffraction analyses.

Cite this article as:

L. Myers Alan, Zhang Yan-Ping, A. Kramer Mark, G. Bornmann William, Kaseb Ahmed, Yang Peiying and T. Tran Hai, A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone, Letters in Organic Chemistry 2012; 9 (10) . https://dx.doi.org/10.2174/157017812803901890