Abstract
The aldol addition of active methylene compounds has been shown to be an important challenge for current organic chemistry, even if the aldol adducts can be particularly useful in the synthesis of complex valuable molecules. Starting from the early unsuccessful attempts employing “standard” methodologies, this review describes the most recent successful one-pot multicomponent procedures and the first examples of synthesis of valuable compounds, both cyclic and acyclic.
Keywords: Aldol reactions, Active methylene compounds, Multi-component reactions, Tandem reactions, Heterocyclic compounds, Organocatalysis, Metal catalysts
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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