Abstract
The use of active methylene reagents in asymmetric catalysis allows interesting and wide synthetic applications for the preparation of highly elaborated enantioenriched compounds. In this review, the chemistry in which sulfur groups, such as a sulfone or more recently even a sulfoxide, in the reagent is utilized to activate the α-methylene position towards either an electrophilic or a nucleophilic attack is compiled. The review is divided into three sections that expose these two activation approaches and the combination of both, and, in each part, the examples are classified according to the reaction type involved. Moreover, the possibility of further functionalization of the products in has also been exemplified.
Keywords: Methylene Reagents, Sulfur Derivatives, Sulfones, Asymmetric Catalysis, Organocatalysis, Metal Catalysis, α-position, β-ketosulfones, α-fluoro-β-ketosulfones, keto-nitroalkanes
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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