Gluten-dependent Intestinal Autoimmune Response

Title:Gluten-dependent Intestinal Autoimmune Response

Volume: 18 Issue: 35

Author(s): Ilma Rita Korponay-Szabo, Zsofia Simon-Vecsei, Luigina De Leo and Tarcisio Not

Affiliation:

Keywords: Genetic gluten intolerance, intestinal anti-transglutaminase antibodies, auto-immunity

Abstract: Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.

Cite this article as:

Rita Korponay-Szabo Ilma, Simon-Vecsei Zsofia, De Leo Luigina and Not Tarcisio, Gluten-dependent Intestinal Autoimmune Response, Current Pharmaceutical Design 2012; 18 (35) . https://dx.doi.org/10.2174/138161212803530826