Abstract
Natural products have not only yielded new and effective drugs but have also provided insight into new mechanisms of action. Paclitaxel (Taxol) as the first promoters of tubulin polymerization plays important roles in the war against cancer and in the exploring new microtubule-binding drugs. The present review summarized the development of paclitaxel and its analogues which can be used as the precurce of synthesis of Taxol and its analogues.
Keywords: Taxol, taxol analogy, taxane, Taxus, anti-cancer, proliferation, phenotype, heredity, motherapeutic, radiotherapy
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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