Abstract
Natural products have not only yielded new and effective drugs but have also provided insight into new mechanisms of action. Paclitaxel (Taxol) as the first promoters of tubulin polymerization plays important roles in the war against cancer and in the exploring new microtubule-binding drugs. The present review summarized the development of paclitaxel and its analogues which can be used as the precurce of synthesis of Taxol and its analogues.
Keywords: Taxol, taxol analogy, taxane, Taxus, anti-cancer, proliferation, phenotype, heredity, motherapeutic, radiotherapy
Current Organic Chemistry
Title:Cancer-Fighting Molecules-Taxol and its Analogs
Volume: 16 Issue: 17
Author(s): Zhi-Yu Ni, Yong Li, Yu-Fang Wang, Si-Ming Wang, Mei Dong and Qing-Wen Shi
Affiliation:
Keywords: Taxol, taxol analogy, taxane, Taxus, anti-cancer, proliferation, phenotype, heredity, motherapeutic, radiotherapy
Abstract: Natural products have not only yielded new and effective drugs but have also provided insight into new mechanisms of action. Paclitaxel (Taxol) as the first promoters of tubulin polymerization plays important roles in the war against cancer and in the exploring new microtubule-binding drugs. The present review summarized the development of paclitaxel and its analogues which can be used as the precurce of synthesis of Taxol and its analogues.
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Cite this article as:
Ni Zhi-Yu, Li Yong, Wang Yu-Fang, Wang Si-Ming, Dong Mei and Shi Qing-Wen, Cancer-Fighting Molecules-Taxol and its Analogs, Current Organic Chemistry 2012; 16 (17) . https://dx.doi.org/10.2174/138527212803251659
DOI https://dx.doi.org/10.2174/138527212803251659 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |

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