Modeling Assisted In Silico Design of Ligand Molecule for DPP IV in Type II Diabetes Mellitus

Title:Modeling Assisted In Silico Design of Ligand Molecule for DPP IV in Type II Diabetes Mellitus

Volume: 9 Issue: 8

Author(s): S. Amuthalakshmi, A. Anton Smith and R. Manavalan

Affiliation:

Keywords: Docking, DPP IV, Imidazolidine, Molecular modeling, Dipeptidyl Peptidase, oligopeptides, neuropeptides, insulinotropic action, cytokines, post-meal glycemic

Abstract: Type II diabetes Mellitus is one of the common diseases worldwide and often recognized as life style disease. The major symptom of this disease is an increase in blood glucose level resulting in polydypsia, polyuria and polyphagia. Molecular modeling was used to design the drug molecules. Docking results showed imidazolidine derivatives have good interaction with the DPP IV receptors. The compound IMA4 showed good orientation and score. This novel compound represents potential scaffold for the design of clinically useful DPP IV inhibitors.

Cite this article as:

Amuthalakshmi S., Anton Smith A. and Manavalan R., Modeling Assisted In Silico Design of Ligand Molecule for DPP IV in Type II Diabetes Mellitus, Letters in Drug Design & Discovery 2012; 9 (8) . https://dx.doi.org/10.2174/157018012802652930

DOI https://dx.doi.org/10.2174/157018012802652930	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X