Update on the Rheumatologic Manifestations of Malignancy

Title: Update on the Rheumatologic Manifestations of Malignancy

Volume: 3 Issue: 3

Author(s): Lianne Marks, Clifton D. Fuller, Parag Sanghvi, Melva Pinn and Charles R. Thomas

Affiliation:

Keywords: neoplastic process, Hypertrophic osteoarthropathy, Vasculitis, Dermatomyositis, lymphoma

Abstract: Malignancy can be accompanied by rheumatologic clinical findings, and these can occur prior to, concurrently with, or after a diagnosis of cancer. Certain clinical information helps to differentiate paraneoplastic symptoms from those more characteristic of classic rheumatologic disorders such as rheumatoid arthritis or systemic lupus erythematosus. Clinicians need to have a higher level of suspicion for malignancy in a patient with rheumatologic manifestations in certain populations. This may be the case in patients with a personal or family history of malignancy, atypical presentations of rheumatologic disorders, and certain clinical situations (such as hypertrophic osteoarthropathy, carcinoma polyarthritis, dermatomyositis, and unilateral sacroiliitis). The current standard of care for patients with a rheumatologic disorder with a known paraneoplastic association (i.e., dermatomyositis) is age-appropriate cancer screening. This review is designed to guide the physician to musculoskeletal signs and symptoms that may be paraneoplastic in origin. Additionally, when the clinician understands current information regarding malignant associations, it will help them decide when it may be appropriate to pursue further investigative work-up or evaluate for recurrence of a known primary tumor.

Cite this article as:

Lianne Marks , Clifton D. Fuller , Parag Sanghvi , Melva Pinn and Charles R. Thomas , Update on the Rheumatologic Manifestations of Malignancy, Current Cancer Therapy Reviews 2007; 3 (3) . https://dx.doi.org/10.2174/157339407781368378