Oxidative Folding of Conotoxins in Immobilized Systems

Title: Oxidative Folding of Conotoxins in Immobilized Systems

Volume: 13 Issue: 1

Author(s): B. R. Green and G. Bulaj

Affiliation:

Keywords: Conotoxins, Oxidative folding, Immobilized, CLEAR-OXTM

Abstract: We tested two alternative oxidation strategies to produce conotoxins α-GI and μ-PIIIA. The peptides were either reversibly immobilized on a solid support and then oxidized, or the immobilized disulfide reagent (CLEAR-OX™) was used to oxidize the peptides. Both strategies appeared more efficient at higher peptide concentrations, consistent with pseudo-dilution effects.

Cite this article as:

Green R. B. and Bulaj G., Oxidative Folding of Conotoxins in Immobilized Systems, Protein & Peptide Letters 2006; 13 (1) . https://dx.doi.org/10.2174/092986606774502162

DOI https://dx.doi.org/10.2174/092986606774502162	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305