The Dialogue Between Endothelial Cells and Monocytes/Macrophages in Vascular Syndromes

Title: The Dialogue Between Endothelial Cells and Monocytes/Macrophages in Vascular Syndromes

Volume: 13 Issue: 17

Author(s): J. Martin, S. Collot-Teixeira, L. McGregor and J. L. McGregor

Affiliation:

Keywords: Inflammation, endothelial cells, monocytes/macrophages, cell adhesion molecules, chemokines, polymorphisms, genomic tools

Abstract: The aim of this chapter is to present and identify potential pharmacological targets in endothelial cell-monocyte interactions leading to vascular syndrome and involving inflammation, coagulation, vascular remodelling and thrombosis. Increasing evidence is indicating that endothelial cells play a key role in atherothombosis by their capacity to attract, bind and allow the extravasation of monocytes to sites of inflammation. Surface expression and/or activation of constituent cell adhesion molecules (for e.g. P-selectin, E-selectin, ICAM-1, and VCAM-1) on endothelial cells together with chemokines such as CXCL8 (IL-8), Platelet-activating factor (PAF), CCL2 and CCL5 (Table 1) allow the rolling, adhesion and extravasation of monocytes. This review focuses on pharmacological targets implicated in endothelial cells interactions with monocytes/macrophages in vascular disease states and on cutting edge genomic tools for the identification and characterization of such targets.

Cite this article as:

Martin J., Collot-Teixeira S., McGregor L. and McGregor L. J., The Dialogue Between Endothelial Cells and Monocytes/Macrophages in Vascular Syndromes, Current Pharmaceutical Design 2007; 13 (17) . https://dx.doi.org/10.2174/138161207780831248