Synthesis and Antiglycation Activity of Kaempferol-3-O-rutinoside (Nicotiflorin)

Title:Synthesis and Antiglycation Activity of Kaempferol-3-O-rutinoside (Nicotiflorin)

Volume: 8 Issue: 3

Author(s): Sajan Lal Shyaula, Ghulam Abbas, Hina Siddiqui, Samina A. Sattar, M. Iqbal Choudhary and Fatima Z. Basha

Affiliation:

Keywords: Kaempferol-3-O-rutinoside, Osyris wightiana Wall. ex Wight, antiglycation activity, cytotoxicity, Diabetes, Nicotiflorin, rhamanopyranosyl , glucopyranoside, cytotoxicity, anaphylactic, immunomodulatory

Abstract: Kaempferol-3-O-α-L-rhamanopyranosyl-(1'''-6'')-β-D-glucopyranoside (1) (Nicotiflorin or kaempferol-3-O-rutinoside), isolated from the aerial parts of Osyris wightiana Wall. ex Wight, exhibited a potent antiglycation activity in vitro. A short and efficient route to kaempferol-3-O-rutinoside (1) is also described in this paper. To study the structure-activity relationship, few other derivatives of kaempferol were also evaluated for their antiglycation activity. Moreover the cytotoxicity analysis was also performed for these compounds. The Structure-Activity Relationship (SAR) studies showed that sugar derivatives of kaempferol possess a promising antiglycation activity.

Cite this article as:

Lal Shyaula Sajan, Abbas Ghulam, Siddiqui Hina, A. Sattar Samina, Iqbal Choudhary M. and Z. Basha Fatima, Synthesis and Antiglycation Activity of Kaempferol-3-O-rutinoside (Nicotiflorin), Medicinal Chemistry 2012; 8 (3) . https://dx.doi.org/10.2174/1573406411208030415