Recent Progress on Synthesis and Activities of Allosamidin and Its Analogues

Gangliang      Huang

doi:10.2174/138955712800626700

Abstract

The pseudotrisaccharide allosamidin 1 is a potent family-18 chitinase inhibitor, and it demonstrates biological activities against insects and fungi. Recent development for the synthesis and activities of compound 1 and its analogues was reviewed. Huang et al. described the solid-phase synthesis of allosamidin 1 and its analogues, which were obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively. It indicated that di-N-acetyl-β-chitobiosyl allosamizoline was strongly against insect chitinase from Bombyx mori. Withers and his coworkers have synthesized chitobiose and chitotriose thiazolines, which exhibit chitinase inhibition activity.

Keywords: Allosamidin, analogues, synthesis, activities, recent development, β-linked, N-iodosuccinimide, oligosaccharides, trimethylsilyl trifluromethanesulfonate