A Novel Synthesis of Multisubstituted Pyrroles via Trisubstituted Olefins and TosMIC Derivatives

Fangli Qiu, Jianwei Wu, Yaohong Zhang, Miao Hu, Feng Yu, Guolin Zhang, Yongping Yu

doi:10.2174/157017812800233778

Abstract

A novel synthesis of multisubstituted pyrroles was developed where in trisubstituted olefins were reacted with p-toluenesulfonylmethyl isocyanide (TosMIC) derivatives. The entire process is operationally simplistic and utilizes mild reaction conditions. Additionally a possible mechanism is proposed.

Keywords: p-toluenesulfonylmethyl isocyanide(TosMIC), trisubstituted olefins, multisubstituted pyrrole, heterocycles, derivatives

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Letters in Organic Chemistry

Title:A Novel Synthesis of Multisubstituted Pyrroles via Trisubstituted Olefins and TosMIC Derivatives

Volume: 9 Issue: 4

Author(s): Fangli Qiu, Jianwei Wu, Yaohong Zhang, Miao Hu, Feng Yu, Guolin Zhang, Yongping Yu

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Keywords: p-toluenesulfonylmethyl isocyanide(TosMIC), trisubstituted olefins, multisubstituted pyrrole, heterocycles, derivatives

Abstract: A novel synthesis of multisubstituted pyrroles was developed where in trisubstituted olefins were reacted with p-toluenesulfonylmethyl isocyanide (TosMIC) derivatives. The entire process is operationally simplistic and utilizes mild reaction conditions. Additionally a possible mechanism is proposed.

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Fangli Qiu, Jianwei Wu, Yaohong Zhang, Miao Hu, Feng Yu, Guolin Zhang, Yongping Yu , A Novel Synthesis of Multisubstituted Pyrroles via Trisubstituted Olefins and TosMIC Derivatives , Letters in Organic Chemistry 2012; 9 (4) . https://dx.doi.org/10.2174/157017812800233778